This session highlights the latest innovations in genomic technologies for diagnosing rare diseases, with a focus on clinical implementation, health equity, and the essential role of genetic counseling. Featured initiatives include Silent Genomes, which aims to reduce healthcare disparities for Indigenous children; GenCOUNSEL, which advances genetic counseling models; BC’s pilot of whole genome sequencing through the national All For One initiative; and Rapidomics 2.0, evaluating the use of long-read sequencing in urgent pediatric cases.